Challenges in Colorectal Cancer

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The MErCuRIC study, a major European collaboration between several countries, including the UK, Belgium, Spain, France, Italy, Czech Republic and Ireland, is investigating a unique combination therapy of immunotherapy and chemotherapy in order to treat patients with the above aberrations. The project is now in Phase 2 and 82 patients have been recruited. The next speaker, Dr Ian Miller RCSI , delineated exciting new research work in their laboratories where there has been a particular focus on new developments in the search for more sensitive and specific biomarkers in order to predict particular types of colorectal cancer.

This lecture complemented the work of the previous speaker in stressing the importance of more precise identification of biomarkers which had the potential to pinpoint more effective therapies for the treatment and control of bowel cancer. The final speaker, Dr Orla Casey Cancer Trials Ireland , detailed the comprehensive programme of research which they had supported in recent years.

In addition to catching colorectal cancer early, the screening cascade, including polypectomy, can prevent cancer from ever developing, Dr. Miller added. Despite the well-known benefits, overall screening rates in the U. To increase screening uptake, internists can do more than opportunistic patient education and encouragement, experts say. Researchers and, increasingly, health systems are addressing challenges, reaching out to patients outside of the clinic, and aiming for a world where getting screened for colorectal cancer is the easy choice, not a pain in the backside.

While colorectal cancer screening rates increased from to , according to the CDC, they continue to lag behind goal levels. In , The target goal is As of , But more than a third of U. Hispanic patients, those who are uninsured, and those who have been in the country fewer than 10 years have lower rates of screening than other populations, according to national data in the August MMWR. Many challenges contribute to a low overall screening uptake. One practical example is present-time bias, said gastroenterologist Shivan J. Logistically, a successful screening cascade has many steps.

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First, clinicians and patients need to know who is eligible for screening. Next, patients need to be screened in a way that doesn't require too many extra steps. Particularly in complicated contexts like this, people also have status quo bias, which means they are more likely to stick with whatever decision is the default, he said. Historically in the U. But fortunately for tentative patients, it is far from the only screening choice.

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In its grade-A recommendation for colorectal cancer screening in average-risk adults ages 50 to 75 years, the USPSTF listed several options for screening strategies: colonoscopy every 10 years, flexible sigmoidoscopy every five years, annual fecal immunochemical test FIT , annual guaiac-based fecal occult blood test FOBT , multitarget stool DNA test every one or three years, computed tomography colonography every five years, and flexible sigmoidoscopy every 10 years plus FIT every year.

To examine status quo bias in the setting of colorectal cancer screening, Dr.

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  6. Mehta led a study that randomized patients to either opt in or opt out of mailed FIT outreach. Mehta said. Despite being the default choice for most, colonoscopy presents a variety of obstacles, such as fear or lack of awareness around the procedure itself, as well as the need for patients to take off work and find an escort to the appointment, noted Gloria D. Providing screening options other than colonoscopy can help increase uptake, especially in traditionally underscreened populations, she said. Of course, there are also financial barriers, particularly in uninsured and underinsured populations.

    One system-level change that could improve screening rates is the Affordable Care Act ACA , whose main provisions went into effect in and would not be fully reflected in data, Dr. Miller noted. In general, usual care was typically visit-based opportunistic screening, and while mailed FIT outreach is increasingly used by systems such as Kaiser, it is still not widespread, noted senior author Daniel S.

    We're going to start doing that … but it's challenging to implement these things. Another challenge with stool testing is that it is ideally performed every year. Most clinics do a colonoscopy-first approach because they are not structured to offer FIT as the default choice, noted Dr. However, Dr. Body fatness at an early age and risk of colorectal cancer.

    Increasing colorectal cancer screening | ACP Internist

    Ogino, S. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 60 , — Hughes, L. Lifestyle, diet, and colorectal cancer risk according to Epi genetic instability: current evidence and future directions of molecular pathological epidemiology.

    Colorectal Cancer Rep. Rescigno, T. Bioactive nutrients and nutrigenomics in age-related diseases. Molecules 22 , pii: E Slattery, M. Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut 67 , — Carr, P. Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses. Oosterhoff, M. The effects of school-based lifestyle interventions on body mass index and blood pressure: a multivariate multilevel meta-analysis of randomized controlled trials.

    Symptoms of bowel cancer

    Bibbins-Domingo, K. Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U. Singh Ranger, G. The role of aspirin in colorectal cancer chemoprevention. Marjoribanks, J. Long-term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst. Gartlehner, G. Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: evidence report and systematic review for the US Preventive Services Task Force. Natural history of colorectal adenomas: birth cohort analysis among 3.

    Cancer Epidemiol. Hewitson, P. Cochrane systematic review of colorectal cancer screening using the fecal occult blood test hemoccult : an update. Scholefield, J. Nottingham trial of faecal occult blood testing for colorectal cancer: a year follow-up. Gut 61 , — Shaukat, A. Long-term mortality after screening for colorectal cancer.

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    Hol, L. Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy. Gut 59 , 62—68 Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among participants of screening colonoscopy.

    Cancer 49 , — Robertson, D. Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gies, A. Quantitative fecal immunochemical tests for colorectal cancer screening. Rex, D. Colorectal cancer screening: recommendations for physicians and patients from the U. Multi-Society Task Force on colorectal cancer. Gastroenterology , — Schreuders, E. Colorectal cancer screening: a global overview of existing programmes.

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    Gut 64 , — Adherence to colorectal cancer screening: four rounds of faecal immunochemical test-based screening. Cancer , 44—49 Imperiale, T. Multitarget stool DNA testing for colorectal-cancer screening. Fecal occult blood versus DNA testing: indirect comparison in a colorectal cancer screening population. Lin, J. Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. Atkin, W. Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial.

    Segnan, N. Holme, O. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial. Schoen, R. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies.

    BMJ , g Kaminski, M. The NordICC Study: rationale and design of a randomized trial on colonoscopy screening for colorectal cancer. Endoscopy 44 , — Doubeni, C. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study.

    In the era of widespread endoscopy use, randomized trials may strongly underestimate the effects of colorectal cancer screening. Public health impact of colonoscopy use on colorectal cancer mortality in Germany and the United States. Wolf, A. Colorectal cancer screening for average-risk adults: guideline update from the American Cancer Society.

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    Frampton, M. Implications of polygenic risk for personalised colorectal cancer screening. Weigl, K.